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Rapid Sequence Induction (RSI) |
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What is new in Rapid Sequence Induction (RSI) |
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Introduction |
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RSI results in rapid unconsciousness (induction) and neuromuscular blockade (paralysis) and is the preferred method of endotracheal intubation for patients who have not fasted and are at greater risk for vomiting and aspiration. The goal of RSI is to intubate the trachea without the use of Bag-Valve-Mask ventilation, which is often necessary when using sedatives alone (titrated to effect). |
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| Standard set-up for RSI. |
| Adjust head/neck position prior to starting. |
| Optimal preoxygenation. |
| Induction agent and suxamethonium. |
| Cricoid cartilage identified before induction by assistant. |
| Light pressure (no more than 10 N force) on the cricoid cartilage prior to loss of consciousness. |
| 30 N cricoid force (equivalent to registering 3 kg on a weighing machine) after loss of consciousness. |
| Direct laryngsocopy undertaken. |
| If difficult try alternative blade (long, straight, McCoy etc), bougie, and the limited amount of external laryngeal manipulation possible with cricoid force. |
| If intubation unsuccessful - stop further attempts. Do not give second dose of relaxant. |
| Announce 'Failed intubation' to stop yourself carrying on with further attempts and to alert assistant that Plan A has failed. |
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What is new in Rapid Sequence Induction (RSI) |
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1. What is the rationale for providing Preoxygenation before tracheal intubation? |
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Preoxygenation allows a safety buffer during periods of hypoventilation and apnea. It extends the duration of safe apnea, defined as the time until a patient reaches a saturation level of 88% to 90%, to allow for placement of a definitive airway. |
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In a patient breathing room air before rapid sequence tracheal intubation (PaO2 90 to 100 mm Hg), desaturation will occur in the 45 to 60 seconds between sedative/paralytic administration and airway placement. |
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Studies by Heller and Watson and Heller et al show markedly increased time to desaturation if the patients received preoxygenation with 100% oxygen rather than room air before tracheal intubation. |
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2. For what period of time should the patient receive Preoxygenation? |
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Ideally, patients should continue to receive preoxygenation until they denitrogenate the functional residual capacity of their lungs sufficiently to achieve greater than 90% end-tidal oxygen level. |
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Three minutes’ worth of tidal-volume breathing (the patient’s normal respiratory pattern) with a high FiO2 source is an acceptable duration of preoxygenation for most patients. This tidal-volume breathing approach can be augmented by asking the patient to exhale fully before the 3-minute period. |
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Cooperative patients can be asked to take 8 vital-capacity breaths (maximal exhalation followed by maximal inhalation). This method generally can reduce the preoxygenation time to approximately 60 seconds. |
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The above times are predicated on a source of FiO2 greater than or equal to 90% and a tightly fitting mask that prevents entrainment of room air. |
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3. Can increasing mean airway pressure augment Preoxygenation? |
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Mean airway pressure may be increased during preoxygenation through the use of techniques such as noninvasive positive-pressure ventilation. If patients have not achieved a saturation greater than 93% to 95% before tracheal intubation, they have a higher likelihood of desaturation during their apneic and tracheal intubation periods. |
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If patients do not achieve this saturation level after 3 minutes of tidal-volume breathing with a high FiO2 source, it is likely that they are exhibiting shunt physiology; any further augmentation of FiO2 will be unhelpful. |
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CPAP masks, noninvasive positive pressure ventilation, or PEEP valves on a bag-valve-mask device should be considered for preoxygenation and ventilation during the onset phase of muscle relaxation in patients who cannot achieve saturations greater than 93% to 95% with high FiO2. |
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4. In what position should the patient receive Preoxygenation? |
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Supine positioning is not ideal to achieve optimal preoxygenation. When one is placed flat, it is more difficult to take full breaths and more of the posterior lung becomes prone to atelectatic collapse, which reduces the reservoir of oxygen contained within the lungs and therefore reduces safe apnea time. |
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Patients preoxygenated in a 20-degree head-up position improves preoxygenation. Similarly Reverse Trendelenburg position (head of stretcher 30 degrees higher than the foot) also improves preoxygenation. |
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Patients should receive preoxygenation in a head-elevated position whenever possible. For patients immobilized for possible spinal injury, reverse Trendelenburg position can be used. |
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5. How long will it take for the patient to desaturate after Preoxygenation? |
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Although breathing at a high FiO2 level will slightly increase the bloodstream stores of oxygen, the primary benefit of preoxygenation is the creation of a reservoir of oxygen in the alveoli. |
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When a patient is breathing room air, 450 mL of oxygen is present in the lungs; this amount increases to 3,000 mL when a patient breathes 100% oxygen for a sufficient time to replace the alveolar nitrogen. A patient breathing room air will have a total oxygen reservoir in the lungs and bloodstream of approximately 1.0 to 1.5 L, whereas an optimally preoxygenated patient will have 3.5 to 4.0 L. |
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Oxygen consumption during apnea is approximately 250 mL/minute (3 mL/kg per minute); in healthy patients, the duration of safe apnea on room air is approximately 1minute compared with approximately 8 minutes when breathing at a high FiO2 level. |
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Oxyhemoglobin dissociation curve demonstrates the SpO2 from various levels of PaO2. Risk categories are
overlaid on the curve. Patients near an SpO2 of 90% are at risk for precipitous desaturation, as demonstrated by the shape of the curve.
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Given the unique variables involved in each ED tracheal intubation, it is impossible to predict the exact duration of safe apnea in a patient. Patients with high saturation levels on room air or after oxygen administration are at lower risk and may maintain adequate oxygen saturation as long as 8 minutes. Critically ill patients and those with values just above the steep edge of the desaturation curve are at high risk of hypoxemia with prolonged tracheal intubation efforts and may desaturate immediately. |
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6. Can apneic oxygenation extend the duration of safe apnea? |
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Apneic oxygenation is not a new concept; it has been described in the medical literature for more than a century, with names such as apneic diffusion oxygenation, diffusion respiration, and mass flow ventilation. |
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Alveoli will continue to take up oxygen even without diaphragmatic movements or lung expansion. In an apneic patient, approximately 250 mL/minute of oxygen will move from the alveoli into the bloodstream. Conversely, only 8 to 20mL/minute of carbon dioxide moves into the alveoli during apnea, with the remainder being buffered in the bloodstream. The difference in oxygen and carbon dioxide movement across the alveolar membrane is due to the significant differences in gas solubility in the blood, as well as the affinity of hemoglobin for oxygen. This causes the net pressure in the alveoli to become slightly subatmospheric, generating a mass flow of gas from pharynx to alveoli. This phenomenon, called apneic oxygenation, permits maintenance of oxygenation without spontaneous or administered ventilations. |
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Under optimal circumstances, a PaO2 can be maintained at greater than 100mm Hg for up to 100 minutes without a single breath, although the lack of ventilation will eventually cause marked hypercapnia and significant acidosis. |
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To provide apneic oxygenation during ED tracheal intubations, the nasal cannula is the device of choice.
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An additional benefit to the use of nasal cannula devices is that they can be left on during the tracheal intubation attempts. This has been described with an acronym, NO DESAT (nasal oxygen during efforts securing a tube); it allows the continued benefits of apneic oxygenation while tracheal intubation techniques are performed.
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The nasal cannula can be placed under a facemask (or bag-valve-mask device) during preoxygenation, and then it remains on, administering oxygen through the nose throughout oral tracheal intubation with direct or video laryngoscopy. |
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A Nasal cannula set at 15 L/minute is the most readily available and effective means of providing apneic oxygenation. |
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7. When and how should we provide manual ventilations during the apneic period? |
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Practitioners should not initiate laryngoscopy before full muscle relaxation to maximize laryngeal exposure and to avoid triggering the patient’s gag reflex and active vomiting just before apnea. |
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Ventilation during the onset phase of muscle relaxation can create alveolar distention and lengthen the duration of safe apnea during tracheal intubation efforts. |
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If a bag-valve-mask device is used during the onset of muscular relaxation, a PEEP valve will provide sustained alveolar distention. Ventilations should be delivered slowly (during 1 to 2 seconds), involve a low volume (6 to 7 mL/kg), and be administered at as low a rate as tolerable for the clinical circumstances (6 to 8 breaths/min). |
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The risk/benefit of active ventilation during the onset phase of muscle relaxants must be carefully assessed in each patient. In patients at low risk for desaturation (_95% saturation), manual ventilation is not necessary. In patients at higher risk (91% to 95% saturation), a risk-benefit assessment should include an estimation of desaturation risk and the presence of pulmonary pathology. In hypoxemic patients, low-pressure, low-volume, low-rate ventilations will be required.
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8. What positioning and maneuvers should the patient receive during the apneic period? |
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Patients should be positioned to maximize upper airway patency before and during the apneic period, using ear-to–sternal notch positioning. Nasal airways may be needed to create a patent upper airway. Once the apneic period begins, the posterior pharyngeal structures should be kept from collapsing backwards by using a jaw thrust. Cricoid pressure may negatively affect apneic oxygenation. |
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9. Does the choice of paralytic agent affect Preoxygenation? |
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In patients at high risk of desaturation, rocuronium may provide a longer duration of safe apnea than succinylcholine. |
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It is hypothesized that the fasciculations induced by succinylcholine may cause increased oxygen use. Pretreatment medications to prevent fasciculations minimize the difference in desaturation times. |
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RISK STRATIFICATION AND CONCLUSIONS: |
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Patients requiring emergency airway management can be risk stratified into 3 groups, according to pulse oximetry after initial application of high-flow oxygen. The recommended techniques to use for patients in each group are shown in Table 1, and a logistic flow of preoxygenation steps is shown in Table 2. |
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Table I: Risk categorization of patients during Preoxygenation: |
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Risk Category, Based on Pulse Oximetry While Receiving High-
Flow Oxygen
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Preoxygenation Period (3 Minutes)
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Onset of Muscle Relaxation (_60 Seconds)
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Apneic Period During Tracheal Intubation (Variable Duration, Depending on Airway Difficulty; Ideally <30 Seconds) |
Low risk, SpO2 96%–100%
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Non rebreather mask with maximal oxygen flow rate |
Non rebreather mask and nasal oxygen at 15 L/min |
Nasal oxygen at 15 L/min |
High risk, SpO2 91%–95%
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Non rebreather mask or CPAP or bag - valve - mask device with PEEP |
Non rebreather mask, CPAP, or bag valve - mask device with PEEP and nasal oxygen at 15 L/min
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Nasal oxygen at 15 L/min |
Hypoxemic, SpO2 90% or less
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CPAP or bag-valve-mask device with PEEP |
CPAP or bag-valve-mask device with PEEP and nasal oxygen at 15 L/min
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Nasal oxygen at 15 L/min |
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Table 2: Logistic flow of Preoxygenation and prevention of desaturation: |
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Sequence of Preoxygenation and prevention of desaturation |
(Assuming 2 oxygen regulators) |
Pre-oxygenation Period |
| Position the patient in semi recumbent position (≈20˚) or in reverse Trendelenberg. Position the patient’s head in the ear-to-sternal- notch position using padding if necessary. |
| Place a nasal cannula in the patient’s nares. Do not hook the nasal cannula to oxygen regulator. |
| Place patient on a non-breather mask at the maximal flow allowed by the oxygen regulator ( at least 15 lpm, but many allow a much greater uncalibrated flow) |
| If patient is not saturating >90% remove face mask and switch to non invasive CPAP by using ventilator, non invasive ventilation machine, commercial CPAP device or BVM with PEEP valve attached. Titrate between 5-15 cm H2O of PEEP to achieve oxygen saturation > 98%. Consider this step in patient saturating 91-95%. |
| Allow patient to breathe at tidal volume for 3 minutes or ask the patient to perform 8 maximal exhalations and inhalations. |
| Attach a BVM to oxygen regulator and set it to maximal flow (at least 15lpm). If the patient required CPAP for preoxygenation, attach a PEEP valve to the BVM set at the patient’s current CPAP level. |
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Apneic Period |
| Push sedative and paralytic ( preferably rocuronium if the patient is at risk for rapid desaturation) |
| Detach face mask from the oxygen regulator and attach the nasal cannula. Drop the flow rate to 15 lpm. |
| Remove the face mask from the patient. |
| Performance jaw thrust to maintain pharyngeal patency. |
| If the patient is high risk (required CPAP for preoxygenation), consider leaving on the CPAP during the apneic period or providing 4-6 ventilation with the BVM with a PEEP valve attached. Maintain a two hand mask seal during the entire apneic period to maintain the CPAP. |
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Intubation Period |
| Leave the nasal cannula on throughout the airway management period to maintain apneic oxygenation. |
If 3 regulators are available, attach reservoir face mask, BVM and nasal cannula to them. If only one regulator is available, consider using a standalone oxygen tank to offer a second source of oxygen. |
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Source: |
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Preoxygenation and Prevention of Desaturation During Emergency Airway Management. Annals of Emergency Medicine, March 2012 (Vol. 59 | No. 3 | Pages 165-175.e1) |
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Ref: |
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Rapid sequence induction – Guidelines. Difficult Airway Society. |