Guillain–Barre syndrome (GBS) is one of the leading cause of non-trauma-induced paralysis in the world. The annual incidence of GBS has been documented to be 0.75–2%/100000 but in case of pregnancy it is 6-24 .

A 26-year-old, primigravida ,in 3rd trimester of pregnancy was admitted in the ICU with acute onset, increasing weakness of all her four limbs for four days .On 1st day, she had normal higher mental functions with bilateral facial nerve palsy, motor power of 1/5 and bilateral plantar flexor response, no signs of respiratory distress, characteristic CSF findings. Supportive care was given with i .v. Dexamethasone , immunoglobulin & low molecular weight heparin (LMWH) .The condition gradually improved by 8th day and Em. LSCS was performed under GA.

GBS is rare in pregnancy but can be managed with good maternal and foetal outcome . Careful evaluation and documentation of the patient’s baseline neurological status, thorough drug history and timely discussion with the patient regarding the risks and benefits of various techniques will help in achieving safe perioperative patient outcome

GBS in pregnancy is a rare, but fatal .Survival rate > 96%; mortality rate is 3–8%, morbidity 5–10% &15% recover completely. In my patient, there were progressive neurological deteriorations which gradually improved .