Case 1: This eight month old infant with Pierre Robin Sequence with associated cleft lip was admitted for cleft lip repair with history of failed intubation at two months of age. Pierre Robin Sequence represents a spectrum of anatomic anomalies whose common features include mandibular hypoplasia, glossoptosis and cleft palate. Child with Pierre Robin Sequence presents difficult intubation due to grossly regressed mandible. Intubation becomes easier as age advances due to catch up growth of mandible, especially in the first few years of life. Surgery postponed for six months to one year has been associated with successful intubation. As our case was an elective surgery, we postponed it for six months. After six months we were able to intubate this child successfully with conventional laryngoscopy in the first attempt itself.

Case 2: This two year old child with Pierre Robin Sequence was admitted for tongue tie release and circumcision. Child had history of two failed intubations at two months and one year of age. Child was intubated with great difficulty using bougie at one and half years for cleft palate repair. This time at two years of age, child was successfully intubated with conventional laryngoscopy in the first attempt. Conclusion: Intubation becomes less difficult and more successful in children with Pierre Robin Sequence as age advances due to mandibular catch up growth.