Laryngoscopy and tracheal intubation may cause profound alteration of the haemodynamic state of the patient. Increase in BP and HR occurs from reflex sympathetic discharge in response to laryngotracheal stimulation. Hence it should be attenuated by appropriate premedicationand rapid intubation. The present study compares the effectiveness of oral clonidine and oral pregabalin premedication in attenuation of pressor response to laryngoscopy and tracheal intubation. Objectives:To compare the effect of oral clonidine with oral pregabalin in attenuation of the pressor response to direct laryngoscopy and tracheal intubation.

50 ASA1 & 2 patients undergoing elective surgical procedures were randomly selected and divided into 2 groups of 25 each. Group A received oralClonidine 0.3 mg and Group B received oral pregabalin 150 mg 90 minutes prior to surgery. HR, SBP, DBP, MAP& RPPwere recorded on arrival in the operating room (baseline), post induction (1 minute), immediately after intubation, at 1, 3, 5 and 10 minutes after intubation.

After intubation, incidence of tachycardia significantly greater with oral pregabalin group. Rise in SBP, DBP, MAP, RPP were also statistically significant in oral pregabalin group than in oral clonidine group.

Attenuation of the pressor responseis seen in both groups. Of the two, oral clonidine is effective in attenuation compared to oral pregabalin.

haemodynamic response, laryngoscopy, intubation, clonidine, pregabalin.