Aims & Objectives:To study the effect of duration of inferior vena cava clamping on hemodynamic changes and Biochemical profile in live donor liver transplant recipients.

Study site Sir Ganga Ram Hospital, New Delhi

Study periodOctober, 2011 to July, 2013 Sample size30

Type of studyProspective Observational Pilot Study

Statistical analysis SPSSprogram for Windows, version 17.0

Group 1 Duration of inferior vena cava clamp < 60 minutes

Group 2 Duration of inferior vena cava clamp > 60 minutes

Hemodynamic parameters (MAP,CO,CI,SVR,SVRI,SVV) were measured, two reading were taken just before and after release of IVC clamp. Postoperatively serum bilirubin, prothrombin time (INR) and arterial blood gas (ABG) were studied till 48 hours.

Results:Both groups were comparable in age, sex, BMI and ASA grade.MAP in Gp1and CO,CI in both groups showed significant difference before and after IVC clamping(P<0.05). No significant change in SVR,SVRI and SVV in the two groups (P>0.05). No significant difference was observed in serum bilirubin inboth the groups (P>0.05). INR showed significant changes from baseline till postoperative day 2 in both the groups (P<0.05). In Gp 2 the base excess showed significant improvement on postoperative day 2 (P<0.05).No significant difference was observed in hemodynamic and biochemical parametersbetween the two groups (P>0.05).

Conclusion: Significant hemodynamic changes were observed after IVC clamping. No correlation was found between duration of inferior vena cava clamping and hemodynamic parameters. Graft function improved on postop day 2.