ABSTRACT : Pain on injection is a major disadvantage of propofol. The most frequently used method to reduce this pain is premixture with lidocaine. Recently, a modified lipid emulsion of propofol containing medium chain triglyceride and long chain triglyceride, in contrast to the usual long chain triglyceride formulation, has been advocated to alleviate pain. This study was designed to investigate whether pain on injection can be reduced in incidence and intensity by a new formulation of propofol.

METHODS : In a randomized, prospective, controlled, double blind study we are comparing the effect of the two solutions on the incidence and intensity of injection pain. A total of 100 ASA grade I and II elective patients with normal pain threshold, will be given either 1% standard propofol (long chain triglyceride) with the addition of 20 mg of lidocaine (1ml of lidocaine 2%) or 1% propofol prepared in a mixture of medium and long chain triglycerides into a vein of the dorsal hand for the induction of anesthesia. Pain was assessed using verbal response, behavioural signs and withdrawal of hand.

RESULTS : As this is an ongoing study the result will be revealed at the time of the conference.

CONCLUSIONS : As this is an ongoing study the result will be revealed at the time of the conference.