Objective: The objective of this study is to compare two of the most popularly used sedative drugs, Dexmedetomidine and Midazolam, given in regional anaesthesia for their anxiolysis, sedative, amnesic, hemodynamic&recovery characteristics, to find out whether Dexmedetomidine and Midazolam suffice the need of “Ideal supplemental sedation”, and as to which stands superior over the other in the same in elderly patients.

Material and Methods: This prospective, randomized study was carried out following approval from Institutional ethics committee. Patients included in this study were informed about the procedure in their own language, and a written informed consent was taken.100, ASA grade 2&3 patients, above 60 years of age, weighing 40 to 90 Kg, of both genders, scheduled for elective procedures, were included.

Results: From the study, it can be said that Dexmedetomidine provided better control for haemodynamic parameters than midazolam, which is essential to provide good surgical field. Respiratory parameters also show less depression in Dexmedetomidine group. Though sedation provided by both drug remained same, analgesia provided by Dexmedetomidine was superior.

Conclusion:Study showed that Intravenous dexmedetomidine and intravenous Midazolam provided similar sedation during Regional Anesthesia. But considering effect of both drugs on haemodynamic and respiratory parameters, Dexmedetomidine can be considered superior than Midazolam as a sedative agent for sedation under Regional Anaesthesia in Elderly.