ABSTRACT : To compare the use of pre treatment with granisetron in comparison with lignocaine in reducing pain on propofol injection.

METHODS : : 104 subjects (ASA I-II) scheduled for elective operations under general anesthesia were allocated into two groups and treated as follows: Group g: 2mg (1mg/ml) granisetron, and group L; 2ml of 2% lignocaine pretreatment using tourniquet followed by 2ml(20mg) of propofol injection and pain assessment was done by a blinded observer and recorded as either severe, moderate, mild or no pain according to the response of the patients to the injection

RESULTS : The incidence of pain was 21.2% in lignocaine group compared to 46.2% in the granisetron group

CONCLUSIONS : : Pretreatment with lignocaine is more effective in controlling pain on propofol injection than granisetron. However granisetron does reduce pain in more than 50% subjects making it an alternative choice due to its additional property to prevent postoperative nausea, vomiting