Unique endocrine hormone of postpartum oxytocin, which is high during lactation is characterized by down-regulated stress responses, amnestic & produce sedation along with GABA secreted during lactation & return to normal quickly when lactation ceases.To assess effect of lactation on dose consumption of Propofol, Sevoflurane&Haemodynamic stability.

A randomized, single blind study on 120 women aged 20-30 yrs of ASA I & II scheduled for tubectomy under general anaesthesia in Bangalore, allocated to 3 groups 40 each, Breast feeding (BF) Withhold feeding (WF) Non feeding (NF) all received standard premedication. HR, MAP, State entropy (SE) values recorded baseline & later at 5min interval. induction with IV propofol 10mg over 5sec every 15 sec until the SE dropped to 45,total dose to achieve SE 45 was recorded, LMA inserted &anaesthesia continued with sevoflurane in 60% N20 and O2. Sevoflurane concentration adjusted to SE (40-60). Consumption of sevoflurane(mL) monitored by GE Datex-Ohemda S/5TM System. Results analyzed by One way analysis of variance, Chi-Square test.

Dose of propofol and sevoflurane was significantly lowered by 25% for BF group, compared to NF & WF (P < 0.05). HR, MAP during surgery were elevated in WF group (P < 0.05) compared NF group & reduced HR, MAP in BF group.

Breast feeding before induction of anaesthesia will reduce dose of propofol&sevoflurane& attenuates stress response to maintain stable haemodynamics.