Measurement of patient health status or quality of life is an important end point in as it represents the patient perception of their outcome of care. Introperative anaesthesia technique and use of drug have an influence in early rehabilitation and reduced morbidity. Use of adequate pain relief techniques, decreasing the use of opioids and increasing multimodal analgesia have been established as an effective measure of early rehabilitation.

135 female subjects posted for elective trans-abdominal hysterectomy under anaesthesia were randomized to receive infusion of Lidocaine(1.5 mg/kg over 15 minutes followed by a 2 mg/kg/h infusion until the end surgery) (Group 1), Normal saline (10 ml over 15 minutes followed by infusion @1ml/kg/hr till end of surgery) (Group 2) and dexmedetomidine (1 mcg/kg over 15 minutes followed by infusion @0.6mcg/kg/hr till end of surgery) (group 3). Intraoperative hemodynamics, extubation variables, postoperative analgesic requirement and quality of recovery score were evaluated

Intraoperative infusion of Lignocaine and dexmedetomidine was associated with early eye opening, response to verbal command. Time to achieve alderate score ≥ 9 in PACU was shortest with Lignocaine infusion. Time for first postoperative analgesic requirement was increased while total analgesic requirement were decreased with use of Lignocaine and dexmedetomidine infusion. Median QoR-40 score were better with the use of Lignocaine and dexmedetomidine compared to control group.

Use of Intraoperative infusion of Lignocaine and dexmedetomidine was associated with early recovery, decreased postoperative analgesic requirement better Quality Of Recovery score signifying greater patient satisfaction.