To assess insertion conditions of LMA. To assess haemodynamic parameters in different groups. To detect the incidence of adverse effects in different groups.

A prospective randomized, double blind study.90 healthy patients posted for elective surgery were randomly allocated into 3 groups of 30 each. All patients were premedicated with glycopyrrolate 0.005mg/kg IV & midazolam 0.02mg/kg IV 30 minutes before surgery.Ten minutes later first group received dexmedetomidine 1µg/kg(groupD), second group received clonidine 1.5µg/kg(group C), third group received ketamine 0.5mg/kg(group K),all diluted in 10ml normal saline.In all the three groups propofol 2mg/kg was used as induction agent.If initial attempt was unsuccessful additional dose of propofol 0.5mg/kg was given.Insertion characteristics were assessed using Young’s criteria for jaw relaxation & modified scheme of Lund &Stovener for overall condition of relaxation.Coughing, gagging, laryngospasm & involuntary movements ,breath holding , lacrimation were assessed.HR,SPO2,NIBP,RR,ECG were recorded.Induction dose of propofol required & top up doses if required were noted.

Mean dose of propofol required in group D was 115±10.35, in group C 119±14.76, & in groupK 124±17.54mg.The incidence of absolute jaw relaxation in group D was 76.6%, in group C 63.3% & in group K was 53.3%. Excellent insertion conditions were observed in 76.6% in group D, 63.3% in group C & 53.3% in group K.Group D patients showed mean decrease in HR.

Dexmedetomidine is better adjuvant to propofol and provides better jaw relaxation and haemodynamic stability compared to clonidine and ketamine.