Ketofol is a combination of ketamine and propofol in a single syringe which can be prepared in any desired concentration. Several gynaecological procedures like tubal sterilization are of short duration and just require analgesia and moderate sedation. A study was conducted with the objectives of comparing two different proportions of ketofol, with reference to the duration and level of sedation, quality of analgesia, haemodynamic and respiratory profiles and to compare all the above effects with the well-tried propofol-fentanyl combination.

This prospective randomised double blind study was study conducted on 60 adult females scheduled for elective tubal sterilization by minilaparotomy at Karnataka Institute of Medical Sciences, Hubli from Jan to Dec 2013. Patients received a slow bolus injection followed by small aliquots of ketofol containing ketamine: propofol (1:1) (group A), ketamine: propofol (1:2) (group B) and fentanyl: propofol (group C) to a predetermined sedation level using Ramsay Sedation Scale. Vital signs, oxygen saturation and incidence of any side effects were recorded.

Ketofol in groups A and B was comparable in onset of sedation, intraoperative sedation score and recovery time (p>0.05). There was no significant difference in haemodynamic and respiratory profile in ketofol groups A and B (P>0.05). Group C showed less sedation, lesser haemodynamic stability and poor analgesia when compared to ketofol groups A and B (p<0.001).

Ketofol (1:1), (1:2) is better than fentanyl-propofol in providing sedoanalgesia with haemodynamic and respiratory stability for tubal sterilization. Sedoanalgesia, haemodynamic and respiratory profiles were comparable between ketofol (1:1) & (1:2) groups.