Award Papers / Dr Kop's Award
To Evaluate The Efficacy Of Preemptive Intravenous Paracetamol Versus Tramadol For Postoperative Analgesia After Lower Abdominal Surgeries In Children.
Insti
Co
Abstract Background: Preemptive analgesia is administration of an analgesic before a painful stimulus, so as to prevent central sensitisation .Intravenous formulation of paracetamol has been introduced and its safety and pharmacokinetic properties have been established for children providing excellent analgesia and avoiding side effects associated with opioids and non- steroidal anti-inflammatory drugs. Present study is to compare the analgesic effects of preemptivei.vparacetamol and tramadol in children undergoing lower abdominal surgeries.
Methods: Sixty four children of ASA physical status I and II, aged 2 to 12 years scheduled for elective lower abdominal surgeries under general anesthesia were recruited for a prospective randomised double blinded study, into group P and group T.Following induction, group P received 15mg/ kg i.vparacetamol and group T 1mg/kg tramadol in 75 ml of normal saline over 15 minutes before surgical stimulus. Postoperative modified objective pain scale(OPS), time to first rescue analgesia(FRA), aldrete score, time to reach aldrete score> 9, sedation scores, parent satisfaction scores and PONV were recorded for 24 hours.
Results: Mean pain scores by OPS in group P and T were similar and statistically insignificant.Time to FRA being 320±20 min in group P as compared to group T 340±30 min. 12.5% patients had PONV in group P as compared to 81.5% in group T(p≤0.05).Mean duration to reach aldrete score of 9 was 11±1.5 min and 16.7±3 min in group P and T respectively(p≤0.05).
Conclusion: Preemptivei.vparacetamol is as efficacious as i.v tramadol for postoperative analgesia with early recovery and lower incidence of PONV in paracetamol group